Thursday December 14th 2017

Laquinimod, an upcoming oral immunomodulatory agent for treatment of multiple sclerosis.

Authors: Varrin-Doyer M, Zamvil SS, Schulze-Topphoff U Abstract Laquinimod is a novel oral drug that is currently being evaluated for the treatment of relapsing-remitting multiple sclerosis (RRMS). Although the mode of action of laquinimod remains to be fully elucidated, current knowledge indicates laquinimod exerts beneficial activities both on the peripheral immune system and within the central nervous system (CNS). The immunomodulatory properties have been deciphered primarily from studies of laquinimod in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). Data indicate that laquinimod has a primary effect on innate immunity. Laquinimod modulates the function of various myeloid antigen presenting cell populations, which then down-regulate pr…

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Laquinimod, an upcoming oral immunomodulatory agent for treatment of multiple sclerosis.

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