Monday December 18th 2017

Laquinimod Interferes With The Development Of Follicular Helper T Cells And Germinal Center B Cells In CNS Autoimmunity (P1.195)

Conclusions: Laquinimod treatment of active EAE or spontaneous OSE interfered with the generation of Tfh cells, maturation of germinal center B cells and production of anti-MOG IgG. These findings indicate that laquinimod can modulate T-B cooperation, and suggest it may be beneficial in humoral autoimmunity.Disclosure: Dr. Varrin-Doyer has nothing to disclose. Dr. Schulze-Topphoff has nothing to disclose. Dr. Pekarek has nothing to disclose. Dr. Zamvil has received personal compensation for activities with Biogen Idec, Teva Neuroscience, EMD Serono-Pfizer, Novartis, and Genzyme. Dr. Zamvil has received research support from the National Institutes of Health, National Multiple Sclerosis Society, the Maisin Foundation, the Guthy Jackson Charitable Foundation, Teva Neuroscience, and Boehringe…

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Laquinimod Interferes With The Development Of Follicular Helper T Cells And Germinal Center B Cells In CNS Autoimmunity (P1.195)

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