Thursday December 14th 2017

Mediation of the Effect of Laquinimod on Disability Progression in Relapsing-Remitting Multiple Sclerosis (RRMS) (P3.195)

CONCLUSIONS: The observed treatment effect of laquinimod in reducing disability progression is not strongly mediated through its effects on either relapses or new T2 lesions activity. This finding supports laquinimod’s novel mechanism of action, i.e., affecting irreversible tissue damage independently from acute inflammatory activity.Study Supported by: Teva Pharmaceutical Industries, Petach Tiqva, Israel.Disclosure: Dr. Comi has received personal compensation for activities with Sanofi-Aventis Pharmaceuticals Inc., Novartis, Merck Serono, Biogen Idec, Bayer Pharmaceuticals Corp., Teva Neuroscience, and Actellion. Dr. Ladkani has received personal compensation for activities with Teva Neuroscience. Dr. Ladkani holds stock and/or stock options in Teva Neuroscience which sponsored rese…

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Mediation of the Effect of Laquinimod on Disability Progression in Relapsing-Remitting Multiple Sclerosis (RRMS) (P3.195)

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