Saturday December 16th 2017

Microstructural Damage to NAWM and GM but Not to Cortical Lesions Contributes to Cognitive Impairment in Multiple Sclerosis: A Diffusion Tensor MRI…

CONCLUSIONS: “Diffuse” damage to the GM and NAWM, rather than intrinsic damage to CLs, seems to play a prominent role in the cognitive impairment of MS patients, probably as a consequence of Wallerian and trans-synaptic degeneration.Study Supported by: a grant from Fondazione Italiana Sclerosi Multipla (FISM/2008/R/13)Disclosure: Dr. Morelli has nothing to disclose. Dr. Rocca has received personal compensation for activities with Biogen Idec and Serono Symposia International Foundation. Dr. Pagani has nothing to disclose. Dr. Preziosa has nothing to disclose. Dr. Copetti has nothing to disclose. Dr. Rodegher has nothing to disclose. Dr. Esposito has nothing to disclose. Dr. Falini has nothing to disclose. Dr. Comi has received personal compensation for activities with Sanofi-Aventis Pharma…

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Microstructural Damage to NAWM and GM but Not to Cortical Lesions Contributes to Cognitive Impairment in Multiple Sclerosis: A Diffusion Tensor MRI…

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