Friday December 15th 2017

ONO-4641 (Ceralifimod) Reduces MRI Lesions and Prevents Disease Progression in an Animal Model of Multiple Sclerosis (P1.219)

CONCLUSIONS: MRI data provide insights into dynamic pathological (inflammation, demyelination) changes in the DA rat EAE model and demonstrate that ONO-4641 can reduce and prevent such changes. Preclinical MRI readouts may provide predictive values for clinical endpoints.Study Supported by: EMD Serono, Inc., Rockland, MA, USA, a subsidiary of Merck KGaA, Darmstadt, Germany.Disclosure: Dr. Huang has received personal compensation for activities with EMD Serono. Dr. Choi has nothing to disclose. Dr. Gray has received personal compensation for activities with EMD Serono as an employee. Dr. Yu has received personal compensation for activities with EMD Serono. Dr. Jenkins has received personal compensation for activities with Sunovion Pharmaceuticals. Dr. Jenkins holds stock and/or stock option…

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ONO-4641 (Ceralifimod) Reduces MRI Lesions and Prevents Disease Progression in an Animal Model of Multiple Sclerosis (P1.219)

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