Monday December 18th 2017

Protease-activated Receptor-1 (PAR-1) and Interleukin-1Beta Act Synergistically in Granzyme b Mediated Neurotoxicity (P1.159)

CONCLUSIONS:These studies demonstrate that PAR-1 and IL-1Beta can act together to promote neurotoxicity. PAR-1 is expressed on neurons adjacent to inflammatory lesions in human brain tissue conferring in vivo risk. PAR-1 upregulation by IL-1Beta is a potential factor in progressive neuronal loss seen in chronic neuroinflammatory diseases.Study Supported by:The NINDS intramural programDisclosure: Dr. Lee has nothing to disclose. Dr. Nath has nothing to disclose. (Source: Neurology)

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Protease-activated Receptor-1 (PAR-1) and Interleukin-1Beta Act Synergistically in Granzyme b Mediated Neurotoxicity (P1.159)

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