Saturday December 16th 2017

Relationship between Immunological Markers and Short-Term Brain Volume Changes in Patients with Relapsing-Remitting Multiple Sclerosis Receiving…

Conclusion: IFN beta-1a SC is associated with reduced brain volume over the first 3 months of treatment, but not over 3-6 months, an effect consistent with treatment-induced pseudoatrophy. Correlation between decreased percentage of CD4+ T-cells producing inflammatory IL-17F and volume reduction is supportive of an early anti-inflammatory therapeutic effect of IFN beta-1a SC.Study supported by: EMD Serono, Inc., Rockland, MA, a subsidiary of Merck KGaA, Darmstadt, Germany, and Pfizer Inc, New York, USA.Disclosure: Dr. Dwyer has received personal compensation for activities with EMD Serono and Claret. Dr. Zivadinov has received personal compensation for activities with Teva, Biogen Idec, EMD Serono, Novartis, Claret and Sanofi-Genzyme. Dr. Zivadinov has received research support from Biogen…

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Relationship between Immunological Markers and Short-Term Brain Volume Changes in Patients with Relapsing-Remitting Multiple Sclerosis Receiving…

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