Saturday February 24th 2018

Does risk stratification decrease the risk of natalizumab-associated PML? Where is the evidence?

The use of natalizumab has likely been limited by its association with progressive multifocal leukoencephalopathy (PML), an infection caused by the human polyomavirus John Cunningham (JC). Three factors were recently identified that contribute to the overall risk of natalizumab-associated PML: (1) Positive serostatus for anti-JCV antibodies, (2) prior use of immunosuppressants, and (3) duration of natalizumab therapy. This risk stratification algorithm has not led to a reduction in the incidence of PML in natalizumab-treated patients with multiple sclerosis between April 2010 and February 2014. This observation may appear perplexing, as treatment duration and JCV serostatus are modifiable risk factors. Potential reasons for the lack of success of companion diagnostics that determine the ov…

Read this article: 

Does risk stratification decrease the risk of natalizumab-associated PML? Where is the evidence?

Leave a Comment

More from category

Multiple sclerosis: Skin cells may help to repair nerve damage
Multiple sclerosis: Skin cells may help to repair nerve damage

Researchers could be on the verge of a new treatment for multiple sclerosis; they reveal how transplanting neural stem [Read More]

Medical News Today: Multiple sclerosis: Skin cells may help to repair nerve damage
Medical News Today: Multiple sclerosis: Skin cells may help to repair nerve damage

Researchers could be on the verge of a new treatment for multiple sclerosis; they reveal how transplanting neural stem [Read More]

Researchers discover how the body skillfully extinguishes inflammation
Researchers discover how the body skillfully extinguishes inflammation

Inflammation needs energy An important source for this energy is oxygen, which is indispensable for the cells of the [Read More]

MS patients who feel stigmatized more likely to suffer from depression
MS patients who feel stigmatized more likely to suffer from depression

People with Multiple Sclerosis -- MS -- who feel stigmatized are more likely to suffer from depression, according to [Read More]

Stigma increases risk of depression for people with Multiple Sclerosis
Stigma increases risk of depression for people with Multiple Sclerosis

(Penn State) People with Multiple Sclerosis -- MS -- who feel stigmatized are more likely to suffer from depression, [Read More]