Saturday February 24th 2018

Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis

We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression in lymphoid organs and the central nervous system; however, edelfosine did not induce global apoptosis. Edelfosine improved the disease course and led to reduced frequencies of CD4+ T cells infiltrating into the central nervous system. Our data suggest edelfosine as an interesting treatment candidate for multiple sclerosis.Highlights: (Source: Journal of Neuroimmunology)

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Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis

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