Monday February 19th 2018

Investigation of magnetization transfer ratio-derived pial and subpial abnormalities in the multiple sclerosis spinal cord

Neuropathological studies in multiple sclerosis have suggested that meningeal inflammation in the brain may be linked to disease progression. Inflammation in the spinal cord meninges has been associated with axonal loss, a pathological substrate for disability. Quantitative magnetic resonance imaging facilitates the investigation of spinal cord microstructure by approximating histopathological changes. We acquired structural and quantitative imaging of the cervical spinal cord from which we calculated magnetization transfer ratio in the outer spinal cord—an area corresponding to the expected location of the pia mater and subpial region—and in spinal cord white and grey matter. We studied 26 healthy controls, 22 people with a clinically isolated syndrome, 29 with relapsing-remit…

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Investigation of magnetization transfer ratio-derived pial and subpial abnormalities in the multiple sclerosis spinal cord

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