Thursday February 22nd 2018

Selective impairments of motor sequence learning in multiple sclerosis patients with minimal disability.

Authors: Tacchino A, Bove M, Roccatagliata L, Luigi Mancardi G, Uccelli A, Bonzano L Abstract Patients with Multiple Sclerosis (PwMS) with severe sensorimotor and cognitive deficits show reduced ability in motor sequence learning. Conversely, in PwMS with minimal disability (EDSS≤2), showing only subtle neurological impairments and no particular deficits in everyday life activities, motor sequence learning has been poorly addressed. Here, we investigated whether PwMS with minimal disability already show a specific impairment in motor sequence learning and which component of this process can be first affected in MS. We implemented a serial reaction time task based on thumb-to-finger opposition movements in response to visual stimuli. Each session included 14 blocks of 120 stimuli …

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Selective impairments of motor sequence learning in multiple sclerosis patients with minimal disability.

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