Thursday January 18th 2018

Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance

Immune surveillance of the CNS is critical for preventing infections; however, there is no accepted experimental model to assess the risk of infection when utilizing disease-modifying agents. We tested two approved agents for patients with multiple sclerosis (MS), glatiramer acetate and fingolimod, in an experimental model of CNS immune surveillance. C57BL/6 mice were infected with the ME49 strain of the neuroinvasive parasite Toxoplasma gondii (T. gondii) and then treated with GA and fingolimod. (Source: Journal of Neuroimmunology)

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Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance

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