Tuesday January 16th 2018

Connectivity‐based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment: A multicenter study

Abstract In this multicenter study, we performed a tractography‐based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Dual‐echo, morphological and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing‐remitting MS patients and 57 healthy controls from six European centers. Patients underwent an extensive neuropsychological assessment. Thalamic connectivity defined regions (CDRs) were segmented based on their cortical connectivity using diffusion tractography‐based parcellation. Between‐group differences of CDRs and cortico‐thalamic tracts DT MRI indices were assessed. A vertex analysis of thalamic …

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Connectivity‐based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment: A multicenter study

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