Thursday January 18th 2018

Mapping human brain capillary water lifetime: high‐resolution metabolic neuroimaging

Shutter‐speed analysis of dynamic‐contrast‐agent (CA)‐enhanced normal, multiple sclerosis (MS), and glioblastoma (GBM) human brain data gives the mean capillary water molecule lifetime (τb) and blood volume fraction (vb; capillary density–volume product (ρ†V)) in a high‐resolution 1H2O MRI voxel (40 μL) or ROI. The equilibrium water extravasation rate constant, kpo (τb−1), averages 3.2 and 2.9 s−1 in resting‐state normal white matter (NWM) and gray matter (NGM), respectively (n = 6). The results (italicized) lead to three major conclusions. (A) kpo differences are dominated by capillary water permeability (PW†), not size, differences. NWM and NGM voxel kpo and vb values are independent. Quantitative analyses of concomitant population‐averaged kpo, vb variations …

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Mapping human brain capillary water lifetime: high‐resolution metabolic neuroimaging

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