Wednesday January 17th 2018

Revisiting the role of mast cells in autoimmunity

Publication date: Available online 23 April 2015 Source:Autoimmunity Reviews Author(s): Xinhua Yu , Anika Kasprick , Frank Petersen Beside their well known role in allergy, mast cells (MCs) are capable to sense multiple signals and have therefore the potential to be involved in many immune responses. MCs are actively present in the target tissues of some autoimmune disorders, suggesting a possible function in the manifestation of such diseases. This idea is strengthened by the evidence that KIT-dependent MC-deficient mice are protected from disease in many mouse models of autoimmunity, including multiple sclerosis, rheumatoid arthritis and autoimmune skin blistering diseases. Thus, the essential role of MCs in autoimmunity not only significantly extends the knowledge of MCs in the immune…

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Revisiting the role of mast cells in autoimmunity

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