Thursday January 18th 2018

Successful modulation of murine lupus nephritis with tuftsin-phosphorylcholine.

Authors: Bashi T, Blank M, Ben-Ami Shor D, Fridkin M, Versini M, Gendelman O, Volkov A, Barshak I, Shoenfeld Y Abstract In areas where helminths infections are common, autoimmune diseases are rare. Treatment with helminths and ova from helminths, improved clinical findings of inflammatory bowel disease, multiple-sclerosis and rheumatoid-arthritis. The immunomodulatory functions of some helminths were attributed to the phosphorylcholine (PC) moiety. We aimed to decipher the tolerogenic potential of Tuftsin-PC (TPC) compound in mice genetically prone to develop lupus. Lupus prone NZBXW/F1 mice received subcutaneously TPC (5 μg/1 ml), 3 times a week starting at 14 weeks age. Autoantibodies were tested by ELISA, T-regulatory-cells by FACS, cytokines profile by RT-PCR and cytokines p…

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Successful modulation of murine lupus nephritis with tuftsin-phosphorylcholine.

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