Tuesday January 16th 2018

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients

Publication date: Available online 10 April 2015 Source:NeuroImage: Clinical Author(s): Amgad Droby , Vinzenz Fleischer , Marco Carnini , Hilga Zimmermann , Volker Siffrin , Joachim Gawehn , Michael Erb , Andreas Hildebrandt , Bernhard Baier , Frauke Zipp Infratentorial lesions have been assigned an equivalent weighting to supratentorial plaques in the new McDonald criteria for diagnosing multiple sclerosis. Moreover, their presence has been shown to have prognostic value for disability. However, their spatial distribution and impact on network damage is not well understood. As a preliminary step in this study, we mapped the overall infratentorial lesion pattern in relapsing-remitting multiple sclerosis patients (N = 317) using MRI, finding the pons (lesion density, 14.25/cm3) and pedu…

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The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients

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