Thursday January 18th 2018

Will CSF biomarkers guide future therapeutic decisions in multiple sclerosis?

Contrast-enhancing lesions (CELs) on MRI of the brain and spinal cord revolutionized care of patients with relapsing-remitting multiple sclerosis (RRMS) by facilitating screening of new therapeutics in economical, but still well-powered, phase II trials, and by providing an assessment of efficacy of approved agents in individual patients. However, CELs capture only a specific aspect of multiple sclerosis (MS) pathology: opening of the blood–brain barrier, which is associated with perivascular inflammation, acute demyelination, and axonal loss in RRMS. As disease progresses, CELs and relapses become less common, and pathology studies indicate that immune cell infiltration shifts from predominantly perivascular locations to diffuse permeation of CNS parenchyma and to consolidation in m…

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Will CSF biomarkers guide future therapeutic decisions in multiple sclerosis?

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