Thursday February 22nd 2018

CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia

In this study, we found that activated astrocytes release CCL11, whereas microglia predominantly express the CCL11 receptor. CCL11 significantly promoted the migration of microglia, and induced microglial production of reactive oxygen species by upregulating nicotinamide adenine dinucleotide phosphate‐oxidase 1 (NOX1), thereby promoting excitotoxic neuronal death. These effects were reversed by inhibition of NOX1. Our findings suggest that CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate‐mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders. GLIA 2015 Main Points In the central nervous system, astrocytes exclusively produce CCL11, and microglia predominantly express…

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CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia

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