Saturday February 24th 2018

Gray matter damage in multiple sclerosis: Impact on clinical symptoms

Publication date: 10 September 2015 Source:Neuroscience, Volume 303 Author(s): Caspar E.P. van Munster, Laura E. Jonkman, Henry C. Weinstein, Bernard M. Uitdehaag, Jeroen J. Geurts Traditionally, multiple sclerosis (MS) is considered to be a disease primarily affecting the white matter (WM). However, the development of some clinical symptoms such as cognitive impairment cannot be fully explained by the severity of WM pathology alone. During the past decades it became clear that gray matter (GM) damage of the brain is also of major importance in patients with MS. Thanks to improved magnetic resonance imaging techniques, the in vivo detection of GM pathology became possible, enabling a better understanding of the manifestation of various clinical symptoms, such as cognitive impairment…

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Gray matter damage in multiple sclerosis: Impact on clinical symptoms

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