Thursday January 18th 2018

HU‐446 and HU‐465, derivatives of the non‐psychoactive cannabinoid cannabidiol, decrease the activation of encephalitogenic T cells

This article is protected by copyright. All rights reserved. The study describes the synthesis and the anti‐inflammatory activities of two isomeric derivatives of the non‐psychoactive cannabinoid, cannabidiol (CBD): HU‐446 and HU‐465 ((‐)‐ and (+)‐8,9‐dihydro‐7‐hydroxy‐CBD, respectively). HU‐446 is a derivative of the natural (‐)‐CBD with negligible affinity towards CB1 or CB2 receptors while HU‐465, a derivative of synthetic (+)‐CBD, is capable of interacting with both. HU‐446 and HU‐465 decrease the in vitro activation of encephalitogenic T cells by MOG35‐55, including their proliferation and IL‐17 release, a key autoimmune cytokine. (Source: Chemical Biology and Drug Design)

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HU‐446 and HU‐465, derivatives of the non‐psychoactive cannabinoid cannabidiol, decrease the activation of encephalitogenic T cells

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