Sunday February 18th 2018

Nicotinic receptor activation negatively modulates pro-inflammatory cytokine production in multiple sclerosis patients.

Authors: Reale M, Di Bari M, Di Nicola M, D’Angelo C, De Angelis F, Velluto L, Tata AM Abstract Acetylcholine (ACh) and its receptors of muscarinic and nicotinic types are involved in the modulation of immune and inflammatory responses. In present work we have characterized the nicotinic receptors expression in PBMC of RR-MS patients and healthy donors (HD) and their ability to modulate pro-inflammatory cytokines. Here we report that the IL-1β e IL-17 levels are significantly increased in serum of RR-MS patients in respect to HD and that the PBMC stimulation with PHA caused a significant increase in pro-inflammatory cytokine levels both in RR-MS and HD subjects, with higher increase of protein release in RR-MS patients than in HD. The PBMC treatment with PHA plus nicotine produced…

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Nicotinic receptor activation negatively modulates pro-inflammatory cytokine production in multiple sclerosis patients.

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