Thursday January 18th 2018

Novel composite MRI scale correlates highly with disability in multiple sclerosis patients

Publication date: Available online 28 August 2015 Source:Multiple Sclerosis and Related Disorders Author(s): Peter Kosa, Mika Komori, Ryan Waters, Tianxia Wu, Irene Cortese, Joan Ohayon, Kaylan Fenton, Jamie Cherup, Tomas Gedeon, Bibiana Bielekova Understanding genotype-phenotype relationships or development/validation of biomarkers requires large multicenter cohorts integrated by universal quantification of crucial phenotypical traits, such as central nervous system (CNS) tissue destruction. We hypothesized that mathematical modeling-guided combination of biologically meaningful, semi-quantitative MRI elements characterized by high signal-to-noise ratio will provide such reliable, universal tool for measuring CNS tissue destruction. We retrospectively graded 15 elements in MRI…

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Novel composite MRI scale correlates highly with disability in multiple sclerosis patients

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