Saturday February 24th 2018

The effect of B-cell depletion in the Theiler’s model of multiple sclerosis

B cell depletion (BCD) is being considered as a treatment for multiple sclerosis (MS), but there are many uncertainties surrounding the use of this therapy, such as its potential effect in individuals with concurrent viral infections. We sought to discover what effect BCD, induced by an anti-CD20 monoclonal antibody, would have on Theiler’s murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD). Mice were injected with the anti-CD20 monoclonal antibody 5D2, 14days before or 14days after infection with TMEV. (Source: Journal of the Neurological Sciences)

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The effect of B-cell depletion in the Theiler’s model of multiple sclerosis

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