Sunday February 18th 2018

Toxin promotes relapsing–remitting experimental autoimmune encephalomyelitis in Lewis rats

Animal models simulate different aspects of human diseases and are essential to get a better understanding of the disease, studying treatments and producing new drugs. Experimental autoimmune encephalomyelitis (EAE) is a preferred model in multiple sclerosis research. Common EAE model in Lewis rats is induced using MBP peptide as a myelin antigen which results in a monophasic disease course. In the present study, EAE was induced in Lewis rats by homogenized guinea pig spinal cord along with or without pertussis toxin (PT). (Source: Journal of Neuroimmunology)

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Toxin promotes relapsing–remitting experimental autoimmune encephalomyelitis in Lewis rats

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